1392. Pharmacokinetic-Pharmacodynamic (PK-PD) Target Attainment Analyses to Support Inhaled ME1100 Dose Selection

Pharmacokinetic/Pharmacodynamic (PK/PD) Relationship-based Approach to Understand the Variability of Central Neurological Effects of Ethanol

Pharmacokinetic/pharmacodynamic (PK/PD) relationships describe the quantitative relationships between the drug-induced effects and the concurrent corresponding drug concentrations in an individual. Since a long time, rough qualitative relationships have been described between neurological presentation and plasma ethanol concentration in acute ethanol ingestion. However, to date, precise quantit...

Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of Anti-Neoplastic Agents

Population Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Target Attainment Analysis for Solithromycin to Support Intravenous Dose Selection in Patients with Community-Acquired Bacterial Pneumonia

with Community-Acquired Bacterial Pneumonia O. O. Okusanya1, S. M. Bhavnani1, A. Forrest1, C. C. Bulik1, B. Jamieson2, D. Oldach2, P. Fernandes2, P. G. Ambrose1 1Institute for Clinical Pharmacodynamics, Latham, NY; 2Cempra Pharmaceuticals, Chapel Hill, NC Abstract Materials and Methods Results Olanrewaju O. Okusanya, Pharm.D., M.S., BCPS Institute for Clinical Pharmacodynamics 43 British Americ...

Use of pharmacokinetic-pharmacodynamic target attainment analyses to support phase 2 and 3 dosing strategies for doripenem.

A doripenem population pharmacokinetic model and Monte Carlo simulations were utilized for dose regimen decision support for future clinical development. Simulation results predict that 500 mg of doripenem administered over 1 h every 8 h would be effective against bacterial strains with MICs less than 2 microg/ml and that less susceptible strains could be treated with prolonged infusions.

In vitro dynamic pharmacokinetic/pharmacodynamic(PK/PD) modeling and PK/PD cutoff of cefquinome against Haemophilus parasuis

BACKGROUND Haemophilus parasuis (H. parasuis) causes Glässer's disease and multisystem infectious disease. It is one of the major causes of nursery mortality in swine herds. Cefquinome (CEQ) is proposed for the treatment of pigs against respiratory tract infection. However, few studies have investigated the PK/PD characteristics and PK/PD cutoff of this drug against H. parasuis. RESULTS A tot...